Skip to main content

Berinert

Pronunciation: BEAR-i-nert
Generic name: complement C1 esterase inhibitor
Dosage form: freeze-dried powder for reconstitution
Drug class: Hereditary angioedema agents

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 5, 2025.

What is Berinert?

Berinert is a man-made form of a protein that occurs naturally in the bloodstream and helps control swelling in the body. People with a condition called hereditary angioedema do not have enough of this protein. Hereditary angioedema can cause attacks of swelling and symptoms such as stomach problems or trouble breathing.

Berinert (generic name C1 esterase inhibitor) is used in adults and adolescents with hereditary angioedema.

Berinert is used to treat attacks of angioedema. The Cinryze and Haegarda brands are used to prevent attacks of angioedema.

Berinert gained FDA approval on October 12, 2009. There is no lower-cost Berinert generic available. 

Warnings

You should not use Berinert if you have ever had a life-threatening allergic reaction to a complement C1 esterase inhibitor.

Before you receive Berinert, tell your doctor if you have a history of stroke or blood clots.

Stop the Berinert infusion and get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing or difficulty breathing; feeling like you might pass out; or swelling of your face, lips, tongue, or throat.

Other serious side effects may include sudden numbness or weakness, chest pain, confusion, pain or swelling, and problems with vision, speech, or balance.

Berinert is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medicine.

Before taking this medicine

You should not use Berinert if you have ever had a life-threatening allergic reaction to a complement C1 esterase inhibitor.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breast-feeding.

Berinert is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risks.

How should I use Berinert?

Use Berinert exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Berinert is injected into a vein through an IV.

You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Read the Berinert Package Insert and all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Berinert is a powder medicine that must be mixed with a liquid (diluent) before using it. Follow all directions carefully. Be sure you understand how to properly mix and store the medicine.

Gently swirl but do not shake the mixed medicine or you may ruin it. Prepare your dose only when you are ready to give yourself an injection.

The powder and diluent mixture should be clear and colorless. Do not use the mixed medicine if it has changed colors or has particles in it. Call your pharmacist for new medicine.

Each single-use vial (bottle) of this medicine is for one use only. Throw it away after one use, even if there is still medicine left inside.

Berinert contains no preservative. Once you have pierced the rubber top of a vial with a needle, you must use that vial right away or throw it away.

Store the unmixed dry powder in a refrigerator or at cool room temperature. Protect from light and do not freeze. Throw away any unused vials after the expiration date on the label has passed.

After mixing Berinert with the diluent, use the injection right away, or store the mixture at room temperature and use it within 8 hours.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Dosing information

Usual Adult Dose of Berinert for Hereditary Angioedema:

For treatment of acute abdominal, facial, or laryngeal attacks of HAE:
Berinert: 20 units per kg body weight intravenously at a rate of approximately 4 mL per minute (500 units/10 mL).

Usual Adolescent Dose of Berinert for Hereditary Angioedema:

For treatment of acute abdominal, facial, or laryngeal attacks of HAE:
13 years and older:
Berinert: 20 units per kg body weight intravenously at a rate of approximately 4 mL per minute (500 units/10 mL)

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after using Berinert?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Berinert side effects

Get emergency medical help if you have signs of an allergic reaction to Berinert: hives; chest tightness, fast heartbeats, feeling light-headed; wheezing or difficult breathing, blue lips or gums; or swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

The most common Berinert side effects are:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What other drugs will affect Berinert?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with complement C1 esterase inhibitors, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does Berinert interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Berinert storage

Berinert is stable for the period indicated by the expiration date on the carton and vial label when stored at temperatures of 2-30°C (36-86°F).

Keep Berinert in its original carton until ready to use.

Do not freeze and protect from light.

Discard any unused product and all used disposable supplies

Berinert ingredients

Each Berinert vial contains 500 IU of C1 esterase inhibitor as a lyophilized concentrate for reconstitution with 10 mL of Sterile Water for Injection, USP provided.

Who makes Berinert?

CSL Behring GmbH makes Berinert.

Berinert Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for Berinert.

Cinryze (C1 Esterase Inhibitor (Human)) - Takeda Pharmaceuticals U.S.A., Inc.
Formulation type Strength
Single-Dose Vial 500 U

View Cinryze information in detail.

Popular FAQ

What is Haegarda used for and how does it work?

Haegarda is a man-made form of a protein called C1 esterase inhibitor (C1-INH), that is injected subcutaneously (under the skin) to prevent angioedema attacks in adults, adolescents, and children over the age of 6 with hereditary angioedema (HAE). Haegarda replaces missing C1-INH, preventing the generation of bradykinin and other substances that increase the permeability of blood vessels. Continue reading

More FAQ

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.